Human Kidney Organoids, Engineered for Predictive Drug Discovery
Closing the gap between preclinical discovery and human clinical success in kidney disease.
We build structurally defined, human-relevant kidney organoid platforms to improve disease modeling, safety assessment, and therapeutic discovery.
A Critical Gap in Drug Development
Kidney diseases affect hundreds of millions worldwide, yet drug development remains severely limited by the lack of predictive human models.
Current preclinical systems — animal models and conventional cell cultures — often fail to capture human-specific kidney biology. More than 90% of drug candidates that clear animal testing still fail in human trials, frequently due to safety issues such as kidney toxicity.
There is a clear need for scalable, human-relevant platforms that can better model kidney structure and function.
Inflection Point
With the FDA's 2025 roadmap to reduce animal testing accelerating the shift toward human-relevant New Approach Methodologies (NAMs) — including organoids — DeepNephro is built for this transition.
A Next-Generation Kidney Organoid Platform
DeepNephro develops advanced human kidney organoid systems designed to recapitulate key structural and functional features of the human kidney — engineered from the ground up to be modular, scalable, and screening-ready.
Spatially patterned, high-order architecture
Reproducible nephron and collecting-duct compartments — including glomeruli with Bowman's space — organized in human-relevant 3D structure.
Human kidney physiological functions
Demonstrated glomerular filtration, tubular albumin reabsorption, and renin-producing endocrine activity — function, not just structure.
Cellular complexity & maturity
Improved representation of the diverse, mature epithelial cell types found in the human kidney.
Progenitor-driven & scalable
Built from expandable nephron and ureteric-bud progenitors — modular, reproducible, and compatible with screening workflows.
Disease-relevant phenotyping & assay readiness
Captures disease-relevant phenotypes with reproducible, assay-ready readouts — enabling faithful modeling of kidney diseases such as PKD.
One Platform, Multiple Frontiers
A versatile foundation for advancing kidney science — from earlier, more predictive discovery to longer-term therapeutic goals.
Disease Modeling
Human-relevant models of kidney disease, including high-fidelity polycystic kidney disease.
Nephrotoxicity Testing
Predictive safety assessment aligned with emerging human-relevant NAM standards.
Therapeutic Discovery
A platform for identifying and validating new therapeutic approaches for kidney disease.
Built on Peer-Reviewed Research
Our platform builds on research published in leading journals, demonstrating advanced kidney organoid systems and disease modeling capabilities.
Founding Team with Deep Kidney Science & Commercial Execution
DeepNephro is led by a team combining expertise in kidney biology, stem cell engineering, and translational development.
Let's Connect
Interested in our platform, partnerships, or learning more? We'd love to hear from you.
Los Angeles, CA 90032